The advancement of artificial intelligence (AI) and the study of neurobiological processes are deeply interlinked, as a deeper understanding of the former can yield valuable insight about the other, and vice versa. Recent neuroscience studies have found that mental state transitions, such as the transition from wakefulness to slow-wave sleep and then to rapid eye movement (REM) sleep, modulate temporary interactions in a class of neurons known as layer 5 pyramidal two-point neurons (TPNs), aligning them with a person’s mental states.